{"product_id":"ketchlo-shampoo","title":"KETCHLO SHAMPOO","description":"\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eKetchalo Antifungal and Antiseptic Shampoo 200ml, brought to you by Vitax, is a pH-balanced, medicated topical shampoo formulated specifically for dogs to address one of the most persistent and uncomfortable challenges in canine skin health: fungal infections, secondary bacterial skin infections, dandruff, and seborrhoeic dermatitis. These conditions, often chronic and recurrent, cause your canine companion significant distress through persistent itching, skin inflammation, scaling, malodour, and self-trauma from scratching. Standard grooming shampoos lack the pharmacological actives needed to resolve these conditions at their dermal source. Ketchalo responds with a clinically purposeful triple-active formula combining Ketoconazole, a powerful broad-spectrum antifungal, with two antiseptic agents, Chlorhexidine Gluconate and Cetrimide, to simultaneously eliminate fungal colonies, suppress bacterial overgrowth responsible for pyoderma, and restore the natural balance of the skin's microenvironment. Formulated with a conditioner advantage that maintains coat softness and manageability through the medicated wash, Ketchalo delivers therapeutic skin care without sacrificing the grooming experience your dog deserves.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eIngredients:\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eKetoconazole:\u003c\/strong\u003e Ketoconazole (C26H28Cl2N4O4) is a synthetic imidazole-class broad-spectrum antifungal agent and the primary therapeutic molecule in this formula. Its mechanism of action targets the ergosterol biosynthesis pathway, which is the fundamental building block of fungal cell membranes. Specifically, Ketoconazole inhibits the cytochrome P450-dependent enzyme lanosterol 14-alpha-demethylase, which is responsible for converting lanosterol to ergosterol. Without ergosterol, the fungal cell membrane becomes structurally deficient and abnormally permeable, leading to leakage of intracellular contents, disruption of membrane-associated enzyme activity, and ultimately fungal cell death. Because ergosterol is found exclusively in fungal cells and not in mammalian cells, Ketoconazole exerts selective toxicity against the pathogen while sparing host tissue. It is effective against the most clinically significant dermatophytes and yeasts affecting dogs, including Malassezia pachydermatis, the primary yeast implicated in seborrhoeic dermatitis, otitis externa, and pruritic skin folds in dogs, as well as dermatophytes such as Trichophyton, Microsporum, and Candida species. When applied topically via a shampoo with adequate contact time, Ketoconazole actively penetrates the stratum corneum to reach the fungal colonies residing at the skin surface and within follicular units, reducing flaking, scaling, itching, and odour associated with yeast overgrowth.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eChlorhexidine Gluconate:\u003c\/strong\u003e Chlorhexidine Gluconate is a broad-spectrum cationic bis-biguanide antiseptic that exerts potent bactericidal and fungicidal activity through a distinctly different mechanism to Ketoconazole, creating a powerful complementary dual-active effect. The positively charged chlorhexidine molecule is attracted by electrostatic force to the negatively charged phospholipid components of bacterial and fungal cell membranes. This electrostatic binding disrupts the structural integrity of the cell membrane, causing increased membrane permeability, leakage of cytoplasmic contents including potassium ions and nucleotides, precipitation of intracellular proteins, and rapid cell death. At higher concentrations, Chlorhexidine causes complete coagulation of intracellular material. Its activity spans a wide range of Gram-positive bacteria, Gram-negative bacteria, yeasts, and certain enveloped viruses, making it particularly valuable in managing pyoderma caused by Staphylococcus pseudintermedius, the most common pathogenic bacterium responsible for canine skin infections. A critical clinical advantage of Chlorhexidine Gluconate is its substantivity: it adsorbs to skin and coat proteins and continues to exert residual antimicrobial activity for hours after rinsing, providing ongoing bacterial suppression between bath sessions. It also contributes to the degreasing, deodorising, and cleansing properties of the shampoo, removing sebum, cellular debris, and bacterial biofilm from the skin surface and within follicular openings.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCetrimide:\u003c\/strong\u003e Cetrimide (cetyltrimethylammonium bromide, CTAB) is a quaternary ammonium compound that functions as a cationic surfactant with potent antiseptic properties. Like Chlorhexidine, Cetrimide acts by disrupting microbial cell membranes through electrostatic interaction with anionic membrane phospholipids, causing membrane destabilisation, loss of selective permeability, and cell lysis in both bacteria and fungi. Cetrimide is particularly effective against Gram-positive bacteria and contributes meaningfully to the treatment of seborrhoeic dermatitis and scabies through its keratolytic and antiseptic activity, breaking down the desquamated keratinous debris and dead skin cells that accumulate in scaling conditions. As a surfactant, Cetrimide also enhances the emulsification and removal of excess sebum, oils, and surface contaminants from the coat and skin, aiding in the physical cleansing process and improving the penetration of the co-formulated antifungal agent into deeper skin layers. The combination of Cetrimide with Chlorhexidine Gluconate creates a synergistic antiseptic pairing that prevents pyoderma and secondary bacterial infections more comprehensively than either agent alone.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003epH-Balanced Shampoo Base with Conditioner:\u003c\/strong\u003e The vehicle base is formulated to a pH closely aligned with the natural canine skin pH range, which is significantly different from the human skin pH. Maintaining appropriate skin pH is critical during medicated washing because an alkaline or overly acidic environment disrupts the acid mantle, the skin's first line of defence against microbial colonisation, and can exacerbate the very conditions the therapeutic actives are working to resolve. The conditioner component within the base restores coat softness, reduces post-wash static and tangling, and helps maintain coat sheen and manageability, ensuring your canine companion's coat is left in healthy condition after every medicated wash.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Vitax","offers":[{"title":"200mL","offer_id":43092341260363,"sku":"3259","price":390.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0665\/4237\/0891\/files\/KETCHLO-SHAMPOO-Animeal-27255777230909_24997026-3023-4ced-9d5c-fa3dccaca550.png?v=1788171145","url":"https:\/\/wagr.in\/products\/ketchlo-shampoo","provider":"WAGR","version":"1.0","type":"link"}